Important Notice: TÜBİTAK's free MA3/ESYA API has been discontinued (1 June 2026). A domestic and independent alternative is ready for software dependent on MA3; we are by your side for the transition. İSG-SİS E-Signature runs entirely on domestic .NET cryptography, with no MA3/ESYA dependency.
What is İSG-SİS E-Signature?
İSG-SİS E-Signature Application is a domestic and independent digital signature platform developed so that everyone — from physicians to corporations, from self-employed professionals to public institutions — can use electronic signatures easily, securely and legally.
Why independent? Your document content is processed on your device; patient or document data is not permanently stored on our servers. Signing, verification and approval processes run without depending on any third-party license.
Products (Platforms)
Signing on every device, everywhere.
Windows Desktop Application
A fully equipped desktop application with token (smart card / e-signature) and mobile signature. It signs Medula e-Prescriptions via a local agent; signs and verifies all file formats and offers 25+ document tools.
Version 12.2 · x64 and x86 · Windows 10/11 · .NET Framework 4.8 · smart card reader + AKİS driver (for token signing)
★ e-Prescription/İBYS, PDF (PAdES) visible signature + QR code + handwritten signature, CAdES/XAdES/ODF/UYAP signing, verification in all formats, document conversion and tools, Health Check.
Browser Extension (Chrome / Edge) — Medula Signing Bridge
For signing Medula e-Prescriptions directly from the browser without needing a desktop agent (localhost). The signature is created via a small local component on your computer using the token. No open ports, no CORS or firewall warnings; the extension works only on isgsis.com.
Chrome Web Store · Edge Add-ons · Local signing component (host)
★ How it works: when you click sign on isgsis.com, the extension steps in; your PIN is requested in the extension's own window (the web page never sees the PIN); the signature is produced on the token in XAdES standard and sent to Medula. No always-on tray app required.
macOS Application
A native (universal) application for Apple Silicon and Intel Macs. e-Prescription, PDF, CAdES signing, verification and Keychain integration.
macOS 12+ · smart card reader (for token signing)
★ The macOS version is 100% on par with Windows.
Android Application
Document/e-Prescription signing and signature verification with SIM mobile signature. Sign with your phone's mobile signature, without a token.
Android 7.0+ · Turkcell / Vodafone / Türk Telekom mobile signature
★ Distributed via Google Play and direct APK.
iOS Application
A native application (SwiftUI) for iPhone/iPad. Document signing, signature detection and sharing with SIM mobile signature.
iOS 16+ · mobile signature
★ Distributed via the App Store.
Web / Mobile Signature (isgsis.com)
e-Prescription signing from the browser. With a token on desktop and SIM mobile signature on mobile; the same flow either way. With mobile signature, the approval comes to your phone.
isgsis.com · token or mobile signature
★ Web-based signing flow requiring no installation.
Features (Signing & Verification)
e-Prescription & İBYS
Medula-compatible XAdES signing; an easy-to-install, zero-UAC local agent for physicians and pharmacies. e-Prescription signing does not consume credit/quota.
PDF (PAdES) Signing
Legal PDF signature with a visible signature stamp, QR code, handwritten signature and free timestamp.
Any File Type — CAdES · XAdES · ODF · UYAP
CAdES (.p7s) detached signature, compatible with enterprise systems; XAdES (.xsig) İmzager-compatible, auto-shrink for the SGK 1 MB limit; ODF embedded (.odt/.ods/.odp); UYAP (.udf) signing.
Signature Verification (all formats)
Verifies PDF, .p7s, .xsig, ODF and UYAP signatures individually or in bulk; detects if a document has been altered, and produces a QR-coded PDF verification report (record).
Mobile Signature
Signing without a token via Turkcell, Vodafone and Türk Telekom mobile signature.
Developer API
REST API + credit/quota; a single integration for HBYS, pharmacy and enterprise software. (MA3 alternative)
Tools (Document Preparation)
İSG-SİS E-Signature does not only sign; it offers 25+ tools that prepare your documents for signing:
The full tool list and step-by-step usage are in the in-app Help → Usage and in the user manual.
User Manual
A from-scratch, screenshot-rich, detailed premium user manual opens from within the app (Help → User Manual); it can also be downloaded as a PDF.
Sections covered
- Installation and first run (token driver, PIN)
- e-Prescription signing (Medula) step by step
- PDF and file signing (PAdES/CAdES/XAdES/ODF/UYAP)
- Visible signature, QR code and handwritten signature
- Signature verification and verification report
- Document conversion and tools
- Signing with mobile signature
- Frequently Asked Questions
- System requirements and troubleshooting
Version History
- ODF (.odt/.ods/.odp) embedded signing and verification added.
- UYAP (.udf) signing and verification added.
- Document converters: PDF ↔ ODT ↔ UYAP.
- ZIP compression and archive extraction tools.
- Auto-shrink for the SGK 1 MB limit in .xsig files.
- Verification now also covers .xsig, ODF and UYAP signatures; a verifiable file types info window.
- File Extensions info button (on the signing screen).
- Splash animation renewed: the main screen opens behind, with a seamless transition.
- Health Check (under Version Info) is retained.
- Premium user manual and Frequently Asked Questions section.
- Browser extension + local signing host (Medula signing bridge).
- The macOS version brought to 100% parity with Windows.
Frequently Asked Questions
MA3/ESYA has shut down, what should I do?
İSG-SİS E-Signature runs on domestic .NET crypto with no MA3/ESYA dependency. You can integrate your existing software seamlessly via the REST API.
Does e-Prescription signing consume quota?
No. During the transition period, e-Prescription signing does not consume credit/quota; other operations consume credit.
Which signature formats are supported?
PAdES (PDF), CAdES (.p7s), XAdES (.xsig / XML), ODF and UYAP (.udf); with timestamp and QR code support.
Can I sign without a token?
Yes. You can sign without a token via Turkcell, Vodafone and Türk Telekom mobile signature.
Is my data safe?
Your document content and PIN are processed on your device; patient/document data is not stored on our servers. We operate in compliance with KVKK.
Is a desktop application required for the browser extension?
No. A full application is not required; only the small local signing component (host) and the token driver are enough.
Download Summary
İSG-SİS E-Signature Application · Version 12.2
e-Prescription Software
Medula-compatible e-Prescription management; a fast, secure workflow for physicians and pharmacies.
ExploreSupport & Contact
Compliant with Electronic Signature Law No. 5070 · KVKK No. 6698 · ETSI (XAdES/CAdES/PAdES) standards.
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